Template:Bicalutamide and other antiandrogens at the androgen and progesterone receptors
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Template:No selflink | AR | PR-B | |||
---|---|---|---|---|---|
Ki (nM) | IC50 (nM) | Imax (%) | IC50 (nM) | Imax (%) | |
Template:No selflink | 117 | 157 | 78 | 1,819 | 88 |
Template:No selflink | 14 | 26 | 48 | >10,000 | 12 |
Template:No selflink | 27 | 15 | 83 | 2,013 | 90 |
Template:No selflink | 22 | 5 | 75 | 0.18 | 96 |
Notes: IC50 values are for functional antagonism. Imax is maximal inhibition. Sources: [1] |
References
- ↑ Hamann LG, Higuchi RI, Zhi L, Edwards JP, Wang XN, Marschke KB, Kong JW, Farmer LJ, Jones TK (1998). "Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines". J. Med. Chem. 41 (4): 623–39. doi:10.1021/jm970699s. PMID 9484511.