Template:Affinities of a selection of androgen receptor ligands at steroid hormone receptors

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Affinities of a selection of androgen receptor
ligands at steroid hormone receptors

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Compound AR ER PR GR MR
Template:No selflink 290 < 0.1 190 4 38
Template:No selflink 180 ? ? ? ?
Template:No selflink 100 ? ? ? ?
Template:No selflink 10 ? ? ? ?
Template:No selflink 1.8 ? ? ? ?
Template:No selflink 0.8 ? ? ? ?
Template:No selflink 0.8 ? ? ? ?
Template:No selflink 300 <0.1 <0.1 <0.1 <0.1
Template:No selflink 150 ? ? ? ?
Template:No selflink 46 <0.1 <0.1 <0.1 <0.1
Template:No selflink 163 <0.1 <0.1 <0.1 <0.1
Template:No selflink 92 <0.1 <0.1 <0.1 <0.1
Notes: Values are RBAs (%). Reference ligands (100%) were testosterone for the AR, estradiol for the ERα and ERβ, progesterone for the PR, dexamethasone for the GR, and aldosterone for the MR. Sources: [1][2][3]

References

  1. Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D (January 1994). "Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor". The Journal of Steroid Biochemistry and Molecular Biology. 48 (1): 111–9. doi:10.1016/0960-0760(94)90257-7. PMID 8136296.
  2. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D (January 1994). "RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism". J. Steroid Biochem. Mol. Biol. 48 (1): 55–60. doi:10.1016/0960-0760(94)90250-X. PMID 8136306.
  3. Battmann T, Branche C, Bouchoux F, Cerede E, Philibert D, Goubet F, Teutsch G, Gaillard-Kelly M (January 1998). "Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders". J. Steroid Biochem. Mol. Biol. 64 (1–2): 103–11. doi:10.1016/S0960-0760(97)00151-9. PMID 9569015.